Cellulose Derivative-Based Bioadhesive Blend Patch for Transdermal Drug Delivery

نویسندگان

چکیده

In this study, matrix-type transdermal patches of glibenclamide were developed using a combination hydrophilic and hydrophobic polymers for investigating the efficacy carriers. A cellulose derivative, HPMC E50, was used as matrix-forming polymer, Eudragit RS 100 polymer. The solvent casting technique employed to develop blend patch formulation chloroform methanol solvent. No drug–polymer interaction observed by FTIR study. membrane permeation study exhibited sustained release up 12 h within range 76.15 ± 2.80% 101.01 0.33% depending on polymeric ratio. increased concentration in different formulations has gradually decreased amount drug penetration through membrane. kinetic analysis showed is best explained zero-order kinetics, followed Higuchi first order. exponent suggested shifting non-Fickian diffusion super case II transport mechanism when increased. It concluded that may be better alternative conventional oral delivery glibenclamide.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Smart Patch for Transdermal Drug Delivery

Transdermal drug delivery of ibuprofen, a well known NSAID has sparked considerable research interest in the recent years. The hydrophobic nature of the drug as well as its water insolubility is a significant deterrent for its uptake through the skin and its bioavailability at the targeted site of pain/inflammation. This work addresses both concerns through a novel microemulsion formulation syn...

متن کامل

Electrospun polymeric nanofibers for transdermal drug delivery

Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

متن کامل

Novel transdermal drug delivery systems

Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...

متن کامل

Bioadhesive Microspheres for Tuberculosis Drug Delivery

Tuberculosis (TB) is an infectious disease that mainly affects the lungs. For the treatment of tuberculosis, conventional drug delivery system fails to achieve efficient drug delivery system fails to achieve efficient drug delivery at the target site. Today, bioadhesive microspheres became a topic of great interest as a novel carrier for drug delivery. Bioadhesive microspheres offers longer ret...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Materials

سال: 2022

ISSN: ['2296-8016']

DOI: https://doi.org/10.3389/fmats.2022.835507